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Differences in effectiveness could also be due to genetic variations in the way in which the body metabolizes clopidogrel or that using certain different drugs with clopidogrel can interfere with how the body metabolizes clopidogrel. ] or that using sure other medication with clopidogrel can interfere with how the body metabolizes clopidogrel. A tumor or abnormality of the adrenal gland, which again leads to extreme cortisol production in the physique. The drug clopidogrel is a "pro-drug" which implies that it needs to be metabolized by the physique before it may be biologically active and have the impact of preventing blood clots. Other reports do not recommend this impact. The FDA is conscious of printed reviews that clopidogrel (marketed as Plavix) is less effective in some patients than it's in others. Some reviews suggest that use of certain PPIs could make clopidogrel much less efficient 3,4by inhibiting the enzyme that converts clopidogrel to the lively form of the drug. In any case, if your associate isn't glad together with your sexual limitations, it may affect the connection negatively.